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Article

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.

The EMBO journal - 15 Dec 1993

Küppers R, Zhao M, Hansmann M L, Rajewsky K

Abstract excerpt

Germinal centres are areas of intense B lymphocyte proliferation inside primary B cell follicles in spleen and lymph nodes. Rearranged V genes from single human B cells, isolated from histological sections of two such structures by micromanipulation, were amplified and sequenced. Cells from the follicular mantle were clonally diverse and largely expressed germline V genes. Germinal centres were dominated by a few...

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Identifiers

PMID: 8262038
DOI: 10.1002/j.1460-2075.1993.tb06189.x
PMCID: PMC413756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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