Article
A specificity-enhancing factor for the ClpXP degradation machine.
Science (New York, N.Y.) - 29 Sept 2000
Levchenko I, Seidel M, Sauer R T, Baker T A
Abstract excerpt
Events that stall bacterial protein synthesis activate the ssrA-tagging machinery, resulting in resumption of translation and addition of an 11-residue peptide to the carboxyl terminus of the nascent chain. This ssrA-encoded peptide tag marks the incomplete protein for degradation by the energy-dependent ClpXP protease. Here, a ribosome-associated protein, SspB, was found to bind specifically to ssrA-tagged...
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