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Article

Arginine phosphorylation marks proteins for degradation by a Clp protease.

Nature - 3 Nov 2016

Trentini Débora Broch, Suskiewicz Marcin Józef, Heuck Alexander, Kurzbauer Robert, Deszcz Luiza, Mechtler Karl, Clausen Tim

Abstract excerpt

Protein turnover is a tightly controlled process that is crucial for the removal of aberrant polypeptides and for cellular signalling. Whereas ubiquitin marks eukaryotic proteins for proteasomal degradation, a general tagging system for the equivalent bacterial Clp proteases is not known. Here we describe the targeting mechanism of the ClpC-ClpP proteolytic complex from Bacillus subtilis. Quantitative affinity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27749819
DOI: 10.1038/nature20122
PMCID: PMC6640040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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