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ClpX Is Essential and Activated by Single-Strand DNA Binding Protein in Mycobacteria

20 Nov 2020

Abstract excerpt

, imposes a major global health burden, surpassing HIV and malaria in annual deaths. The ClpP1P2 proteolytic complex and its cofactor ClpX are attractive drug targets, but their precise cellular functions are unclear. This work confirms ClpX's essentiality and describes a novel interaction between ClpX and SSB, a component of the DNA replication machinery. Further, we demonstrate that a loss of ClpX is sufficient...

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PMID: 33229461
DOI: 10.1128/jb.00608-20

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