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Article

Altered tethering of the SspB adaptor to the ClpXP protease causes changes in substrate delivery.

The Journal of biological chemistry - 13 Apr 2007

McGinness Kathleen E, Bolon Daniel N, Kaganovich Mark, Baker Tania A, Sauer Robert T

Abstract excerpt

SspB is a dimeric adaptor protein that increases the rate at which ssrA-tagged substrates are degraded by tethering them to the ClpXP protease. Each SspB subunit consists of a folded domain that forms the dimer interface and a flexible C-terminal tail. Ternary delivery complexes are stabilized by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17317664
DOI: 10.1074/jbc.M610671200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17317664-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Altered tethering of the SspB adaptor to the ClpXP protease causes changes in substrate delivery.PMID 17317664Read ↗

Flexible linkers leash the substrate binding domain of SspB to a peptide module that stabilizes delivery complexes with the AAA+ ClpXP protease.Semantic proximity Read ↗

A specificity-enhancing factor for the ClpXP degradation machine.Semantic proximity Read ↗

Altered specificity of a AAA+ protease.Semantic proximity Read ↗

The Intrinsically Disordered N-terminal Extension of the ClpS Adaptor Reprograms Its Partner AAA+ ClpAP Protease.Semantic proximity Read ↗

Versatile modes of peptide recognition by the ClpX N domain mediate alternative adaptor-binding specificities in different bacterial species.Semantic proximity Read ↗

Inducible protein degradation in Bacillus subtilis using heterologous peptide tags and adaptor proteins to target substrates to the protease ClpXP.Semantic proximity Read ↗

Turnover of endogenous SsrA-tagged proteins mediated by ATP-dependent proteases in Escherichia coli.Semantic proximity Read ↗

Insight into the RssB-Mediated Recognition and Delivery of σs to the AAA+ Protease, ClpXP.Semantic proximity Read ↗

Adaptor bypass mutations of Bacillus subtilis spx suggest a mechanism for YjbH-enhanced proteolysis of the regulator Spx by ClpXP.Semantic proximity Read ↗

Characterization of a trap mutant of the AAA+ chaperone ClpB.Semantic proximity Read ↗

The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system.Semantic proximity Read ↗

ClpB chaperone passively threads soluble denatured proteins through its central pore.Semantic proximity Read ↗

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