Article
SmpB, a unique RNA-binding protein essential for the peptide-tagging activity of SsrA (tmRNA).
The EMBO journal - 1 Jul 1999
Karzai A W, Susskind M M, Sauer R T
Abstract excerpt
In bacteria, SsrA RNA recognizes ribosomes stalled on defective messages and acts as a tRNA and mRNA to mediate the addition of a short peptide tag to the C-terminus of the partially synthesized nascent polypeptide chain. The SsrA-tagged protein is then degraded by C-terminal-specific proteases. SmpB, a unique RNA-binding protein that is conserved throughout the bacterial kingdom, is shown here to be an essential...
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