Article
An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2017
Clay Gwendolyn M, Valadares Diogo G, Graff Joel W, Ulland Tyler K, Davis Richard E, Scorza Breanna M, Zhanbolat Bayan Sudan, Chen Yani, Sutterwala Fayyaz S, Wilson Mary E
Abstract excerpt
The role of the nucleotide-binding domain and leucine-rich repeat containing receptor NLRP10 in disease is incompletely understood. Using three mouse strains lacking the gene encoding NLRP10, only one of which had a coincidental mutation in DOCK8, we documented a role for NLRP10 as a suppressor of the cutaneous inflammatory response to Leishmania major infection. There was no evidence that the enhanced local...
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