Article
Mice lacking both granulocyte colony-stimulating factor (CSF) and granulocyte-macrophage CSF have impaired reproductive capacity, perturbed neonatal granulopoiesis, lung disease, amyloidosis, and reduced long-term survival.
Blood - 15 Oct 1997
Seymour J F, Lieschke G J, Grail D, Quilici C, Hodgson G, Dunn A R
Abstract excerpt
Mice lacking granulocyte colony-stimulating factor (G-CSF) are neutropenic with reduced hematopoietic progenitors in the bone marrow and spleen, whereas those lacking granulocyte-macrophage colony-stimulating factor (GM-CSF) have impaired pulmonary homeostasis and increased splenic hematopoietic...
Topics
- Aging
- Amyloidosis
- Animals
- Genotype
- Granulocyte Colony-Stimulating Factor
- Granulocyte-Macrophage Colony-Stimulating Factor
- Infertility
- Leukopoiesis
- Longevity
- Lung Diseases
- Mice
- Mice, Knockout
- Multivariate Analysis
- Neutropenia
- Phenotype