Up-regulation of T helper 2 and down-regulation of T helper 1 cytokines during murine retrovirus-induced immunodeficiency syndrome enhances susceptibility of a resistant mouse strain to Leishmania amazonensis.

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Article

Up-regulation of T helper 2 and down-regulation of T helper 1 cytokines during murine retrovirus-induced immunodeficiency syndrome enhances susceptibility of a resistant mouse strain to Leishmania amazonensis.

The American journal of pathology - 1 Mar 1995

Barral-Netto M, da Silva J S, Barral A, Reed S

Abstract excerpt

Resistance to and recovery from leishmania infection is dependent on cell-mediated immunity. C57BL/6 mice are resistant to Leishmania amazonensis (La) infection but susceptible to LP-BM5 murine leukemia virus (MuLV) infection. MuLV infection leads to a state of immunodeficiency characterized by s...

Topics

Animals
Cytokines
Disease Susceptibility
Female
Genetic Predisposition to Disease
Leishmaniasis
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Murine Acquired Immunodeficiency Syndrome
Retroviridae Infections
T-Lymphocytes, Helper-Inducer

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Identifiers

PMID: 7887446
PMCID: PMC1869162

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7887446-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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