Inhibition of the differentiation of human myeloid cell lines by redox changes induced through glutathione depletion.

doi:10.1042/bj3010649

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Article

Inhibition of the differentiation of human myeloid cell lines by redox changes induced through glutathione depletion.

The Biochemical journal - 1 Aug 1994

Esposito F, Agosti V, Morrone G, Morra F, Cuomo C, Russo T, Venuta S, Cimino F

Abstract excerpt

We have investigated the effect of redox changes in vivo on the differentiation of two human myeloid cell lines, HL-60 and KG-1. The glutathione-depleting agent diethyl maleate (DEM) prevented the development of differentiated features in response to phorbol esters, including adherence of the cells to plastic surfaces and repression of the myeloperoxidase and CD34 genes. Moreover, DEM abolished phorbol...

Topics

Antigens, CD
Antigens, CD34
Base Sequence
Cell Adhesion
Cell Differentiation
DNA-Binding Proteins
Early Growth Response Protein 1
Glutathione
Granulocytes
Humans
Immediate-Early Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, Erythroblastic, Acute

Leukemia, Promyelocytic, Acute

Maleates

Molecular Sequence Data

Oxidation-Reduction

Peroxidase

Phenotype

Source

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Identifiers

PMID: 7519845
DOI: 10.1042/bj3010649
PMCID: PMC1137037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7519845-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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