Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RasGRP1 confers the phorbol ester-sensitive phenotype to EL4 lymphoma cells.

Molecular pharmacology - 1 Jan 2007

Han Shujie, Knoepp Stewart M, Hallman Mark A, Meier Kathryn E

Abstract excerpt

The murine EL4 lymphoma cell line exists in variants that are either sensitive or resistant to the tumor promoter phorbol 12-myristate 13-acetate (PMA). In sensitive EL4 cells, PMA causes robust Erk mitogen-activated protein kinase activation that results in growth arrest. In resistant cells, PMA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Division
Share to Cell Line, Tumor
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

Share to Kinetics

Share to Lymphoma

Share to RNA, Small Interfering

Share to Tetradecanoylphorbol Acetate

Source

Identifiers

PMID: 17065239
DOI: 10.1124/mol.106.028639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17065239-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RasGRP1 confers the phorbol ester-sensitive phenotype to EL4 lymphoma cells.PMID 17065239Read ↗

The Diacylglycerol-dependent translocation of ras guanine nucleotide-releasing protein 4 inside a human mast cell line results in substantial phenotypic changes, including expression of interleukin 13 receptor alpha2.Semantic proximity Read ↗

Deregulated expression of RasGRP1 initiates thymic lymphomagenesis independently of T-cell receptors.Semantic proximity Read ↗

Loss of RASGRP1 in humans impairs T-cell expansion leading to Epstein-Barr virus susceptibility.Semantic proximity Read ↗

Targeted deletion of RasGRP1 impairs skin tumorigenesis.Semantic proximity Read ↗

K562 cells resistant to phorbol 12-myristate 13-acetate-induced growth arrest: dissociation of mitogen-activated protein kinase activation and Egr-1 expression from megakaryocyte differentiation.Semantic proximity Read ↗

Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis.Semantic proximity Read ↗

RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis.Semantic proximity Read ↗

Mutant RAS selectively promotes sensitivity of myeloid leukemia cells to apoptosis by a protein kinase C-dependent process.Semantic proximity Read ↗

Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3.Semantic proximity Read ↗

Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells.Semantic proximity Read ↗

Modulation of phospholipase D by Ras proteins mediated by its effectors Ral-GDS, PI3K and Raf-1.Semantic proximity Read ↗

An epidermal growth factor receptor/Gab1 signaling pathway is required for activation of phosphoinositide 3-kinase by lysophosphatidic acid.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.