Article
Influences of p53 deficiency on the apoptotic response, DNA damage removal and mutagenesis in UVB-exposed mouse skin.
Mutagenesis - 1 Jul 2010
Ikehata Hironobu, Okuyama Ryuhei, Ogawa Eisaku, Nakamura Shingo, Usami Atsuko, Mori Toshio, Tanaka Kiyoji, Aiba Setsuya, Ono Tetsuya
Abstract excerpt
p53 suppresses the genomic instability provoked by genotoxic agents. Ultraviolet (UV) B induces skin cancers by producing DNA damage and mutations in the skin genome, whereas the skin tissue responds to the UVB insult with cell cycle arrest and apoptosis as well as damage exclusion by DNA repair. To address the p53 contribution to these skin responses in vivo, we analyzed the time course of DNA damage removal,...
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