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Article

UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice.

DNA repair - 28 Feb 2002

van der Horst Gijsbertus T J, Meira Lisiane, Gorgels Theo G M F, de Wit Jan, Velasco-Miguel Susana, Richardson James A, Kamp Yvonne, Vreeswijk Maaike P G, Smit Bep, Bootsma Dirk, Hoeijmakers Jan H J, Friedberg Errol C

Abstract excerpt

Cockayne syndrome (CS) is an inherited photosensitive neurodevelopmental disorder caused by a specific defect in the transcription-coupled repair (TCR) sub-pathway of NER. Remarkably, despite their DNA repair deficiency, CS patients do not develop skin cancer. Here, we present a mouse model for CS complementation group A. Like cells from CS-A patients, Csa-/- mouse embryonic fibroblasts (MEFs): (i) are...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12509261
DOI: 10.1016/s1568-7864(01)00010-6

Genes

CPD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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