Article
[Analysis of the p53 gene status of lymph node metastasis in the head and neck region in occult primary cancer].
Laryngo- rhino- otologie - 1 Jul 2000
Gottschlich S, Schuhmacher O, Görögh T, Hoffmann M, Maune S
Abstract excerpt
BACKGROUND: Lymph node metastasis in the head and neck region with occult primary cancer are a fairly rare tumor entity in head and neck cancer. Tumor biological parameters as well as mechanism and cause for the development of this so called "cancer of unknown primary" (CUP) are not well investigated in head and neck cancer. Mutations of the p53 tumor suppressor gene are the most prevalent genetic alteration of...
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