Article
[Immunohistochemical detection and prognostic significance of p53 in the primary tumor of breast carcinoma patients].
Geburtshilfe und Frauenheilkunde - 1 May 1995
Beck T, Weller E, Weikel W, Brumm C, Wilkens C, Knapstein P G
Abstract excerpt
The occurrence of the p 53 gene mutation in breast carcinoma tumour cells, leads to the accumulation of mutant p 53 protein types, whose consequence is the loss of the negative regulation normally exercised by the p 53 gene, which is considered to act as a tumour suppressor. It is possible to demonstrate the presence of mutant p 53 protein types in tumour cell nuclei by applying immunohistochemical procedures to...
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