Article
Immunoperoxidase staining for cytokeratins 8 and 18 is very sensitive for detection of occult node metastasis of colorectal cancer: a comparison with genetic analysis of K-ras.
Histopathology - 1 Mar 1998
Sasaki M, Watanabe H, Jass J R, Ajioka Y, Kobayashi M, Hatakeyama K
Abstract excerpt
AIMS: Recent reports suggest that genetic examination of K-ras or p53 mutation is more sensitive for the detection of occult lymph node metastasis in colorectal carcinomas than conventional examination by haematoxylin and eosin (H & E) staining or immunohistochemistry for gene products. The aim o...
Topics
- Aged
- Aged, 80 and over
- Case-Control Studies
- Colorectal Neoplasms
- Female
- Genes, p53
- Genes, ras
- Humans
- Immunoenzyme Techniques
- Keratins
- Lymphatic Metastasis
- Male
- Middle Aged
- Mutation
- Prognosis
- Sensitivity and Specificity