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Induction of Human Fetal Globin Gene Expression by a Novel Erythroid Factor, NF-E4

15 Oct 2000

Abstract excerpt

The stage selector protein (SSP) is a heteromeric complex involved in preferential expression of the human gamma-globin genes in fetal-erythroid cells. We have previously identified the ubiquitous transcription factor CP2 as a component of this complex. Using the protein dimerization domain of CP2 in a yeast two-hybrid screen, we have cloned a novel gene, NF-E4, encoding the tissue-restricted component of the...

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PMID: 11003662
DOI: 10.1128/mcb.20.20.7662-7672.2000

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