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Article

Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming

1 Dec 2018

Abstract excerpt

During development, hematopoietic stem and progenitor cells (HSPCs) arise from specialized endothelial cells by a process termed endothelial-to-hematopoietic transition (EHT). The genetic program driving human HSPC emergence remains largely unknown. We previously reported that the generation of hemogenic precursor cells from mouse fibroblasts recapitulates developmental hematopoiesis. Here, we demonstrate that...

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PMID: 30517869
DOI: 10.1016/j.celrep.2018.11.032

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