Differential Binding of the NFE3 and CP1/NFY Transcription Factors to the Human γ- and ∊-Globin CCAAT Boxes

Abstract excerpt

Naturally occurring nondeletional mutations affecting the distal CCAAT box of the human gamma-globin gene promoter result in hereditary persistence of fetal hemoglobin in adult life. Although the distal CCAAT box is the target of several factors, including CP1/NFY, CDP, GATA-1 and NFE3, only NFE3 binding activity is consistently sensitive to well characterized mutations in this region such as G-117-->A,...