Article
Regulation of embryonic/fetal globin genes by nuclear hormone receptors: a novel perspective on hemoglobin switching.
The EMBO journal - 1 Feb 1999
Filipe A, Li Q, Deveaux S, Godin I, Roméo P H, Stamatoyannopoulos G, Mignotte V
Abstract excerpt
The CCAAT box is one of the conserved motifs found in globin promoters. It binds the CP1 protein. We noticed that the CCAAT-box region of embryonic/fetal, but not adult, globin promoters also contains one or two direct repeats of a short motif analogous to DR-1 binding sites for non-steroid nuclear hormone receptors. We show that a complex previously named NF-E3 binds to these repeats. In transgenic mice,...
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