Article
Regulation of embryonic/fetal globin genes by nuclear hormone receptors: a novel perspective on hemoglobin switching.
The EMBO journal - 1 Feb 1999
Filipe A, Li Q, Deveaux S, Godin I, Roméo P H, Stamatoyannopoulos G, Mignotte V
Abstract excerpt
The CCAAT box is one of the conserved motifs found in globin promoters. It binds the CP1 protein. We noticed that the CCAAT-box region of embryonic/fetal, but not adult, globin promoters also contains one or two direct repeats of a short motif analogous to DR-1 binding sites for non-steroid nucle...
Topics
- Animals
- Base Sequence
- CCAAT-Enhancer-Binding Proteins
- COUP Transcription Factors
- Cell Line
- DNA
- DNA-Binding Proteins
- Embryonic and Fetal Development
- Genes, Switch
- Globins
- Hemoglobins
- Humans
- Mice
- Mice, Transgenic
- Mutation
- Nuclear Proteins
- Promoter Regions, Genetic
- RNA, Messenger