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Article

Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.

Proceedings of the National Academy of Sciences of the United States of America - 29 Oct 1996

Perkins A C, Gaensler K M, Orkin S H

Abstract excerpt

Globin genes are subject to tissue-specific and developmental stage-specific regulation. A switch from human fetal (gamma)-to adult (beta)-globin expression occurs within erythroid precursor cells of the adult lineage. Previously we and others showed by targeted gene disruption that the zinc finger gene, erythroid Krüppel-like factor (EKLF), is required for expression of the beta-globin gene in mice, presumably...

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Identifiers

PMID: 8901569
DOI: 10.1073/pnas.93.22.12267
PMCID: PMC37979

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Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.PMID 8901569Read ↗

Role of Erythroid Kruppel-like Factor in Human γ- to β-Globin Gene SwitchingSemantic proximity Read ↗

The GATA-E box-GATA motif in the EKLF promoter is required for in vivo expression.Semantic proximity Read ↗

Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region.Semantic proximity Read ↗

FKLF, a Novel Krüppel-Like Factor That Activates Human Embryonic and Fetal β-Like Globin GenesSemantic proximity Read ↗

KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic β-like globin genes in vivoSemantic proximity Read ↗

Isolation, Genomic Structure, and Expression of Human Erythroid Krüppel-Like Factor (EKLF)Semantic proximity Read ↗

Erythroid Kruppel‐like factor (EKLF) is recruited to the <i>γ</i>‐<i>globin</i> gene promoter as a co‐activator and is required for <i>γ</i>‐<i>globin</i> gene induction by short‐chain fatty acid derivativesSemantic proximity Read ↗

Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF.Semantic proximity Read ↗

Loss of LKLF function results in embryonic lethality in mice.Semantic proximity Read ↗

Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor.Semantic proximity Read ↗

Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice.Semantic proximity Read ↗

Distinct modes of gene regulation by a cell-specific transcriptional activator.Semantic proximity Read ↗

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