Article
Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.
Proceedings of the National Academy of Sciences of the United States of America - 29 Oct 1996
Perkins A C, Gaensler K M, Orkin S H
Abstract excerpt
Globin genes are subject to tissue-specific and developmental stage-specific regulation. A switch from human fetal (gamma)-to adult (beta)-globin expression occurs within erythroid precursor cells of the adult lineage. Previously we and others showed by targeted gene disruption that the zinc fing...
Topics
- Adult
- Animals
- Cells, Cultured
- DNA-Binding Proteins
- Erythroid Precursor Cells
- Fetal Hemoglobin
- Gene Expression Regulation, Developmental
- Genotype
- Globins
- Humans
- Kruppel-Like Transcription Factors
- Mice
- Models, Biological
- RNA, Messenger
- Transcription Factors
- Transcription, Genetic
- Zinc Fingers