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Article

Is TP53 dysfunction required for BRCA1-associated carcinogenesis?

Molecular and cellular endocrinology - 10 Sept 1999

Schuyer M, Berns E M

Abstract excerpt

The identification of the breast/ovarian susceptibility genes, BRCA1 and BRCA2 was an important advancement in the field of breast and ovarian cancer research. About 40-50% of site specific hereditary breast cancers and up to 80% of hereditary breast-ovarian cancers result from mutations in the BRCA1 gene. Although BRCA1 mediates multiple functions in the cell, including a role in DNA damage repair and gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10580847
DOI: 10.1016/s0303-7207(99)00117-3

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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BRCA1 gene: function and deficiency.Semantic proximity Read ↗

Increased frequency of TP53 mutations in BRCA1 and BRCA2 ovarian tumours.Semantic proximity Read ↗

The role of TP53 in breast cancer development.Semantic proximity Read ↗

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