Article
The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins.
Biological chemistry - 1 Feb 1999
Irminger-Finger I, Siegel B D, Leung W C
Abstract excerpt
About half of the familial breast cancer cases are found to bear mutations in the breast cancer susceptibility gene 1 (BRCA1). The majority of BRCA1 mutations produce a truncated protein and BRCA1-associated breast tumors exhibit a number of defined tumor phenotypes. The function of BRCA1 has been examined in gene knockout mice in which the nullizygous mice die early in utero, but this lethality can be partially...
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