Article
Understanding the functions of BRCA1 in the DNA-damage response.
Biochemical Society transactions - 1 Jun 2009
Yun Maximina H, Hiom Kevin
Abstract excerpt
Inheritance of a mutation in BRCA1 (breast cancer 1 early-onset) results in predisposition to early-onset breast and ovarian cancer. Tumours in these individuals arise after somatic mutation or loss of the wild-type allele. Loss of BRCA1 function leads to a profound increase in genomic instability involving the accumulation of mutations, DNA breaks and gross chromosomal rearrangements. Accordingly, BRCA1 has been...
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