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Article

Regulation of p53 by TopBP1: a Potential Mechanism for p53 Inactivation in Cancer

16 Mar 2009

Abstract excerpt

Proper control of the G(1)/S checkpoint is essential for normal proliferation. The activity of p53 must be kept at a very low level under unstressed conditions to allow growth. Here we provide evidence supporting a crucial role for TopBP1 in actively repressing p53. Depletion of TopBP1 upregulates p53 target genes involved in cell cycle arrest and apoptosis and enhances DNA damage-induced apoptosis. The...

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Identifiers

PMID: 19289498
DOI: 10.1128/mcb.01140-08

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Regulation of p53 by TopBP1: a Potential Mechanism for p53 Inactivation in CancerPMID 19289498Read ↗

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