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Article

p53, BRCA1 and breast Cancer chemoresistance.

Advances in experimental medicine and biology - 1 Jan 2007

Scata Kimberly A, El-Deiry Wafik S

Abstract excerpt

The tumor suppressor genes p53 and BRCA1 are involved in hereditary as well as sporadic breast cancer development and therapeutic responses. While p53 mutations contribute to resistance to chemo- and radiotherapy, BRCA1 dysfunction leads to enhanced sensitivity to DNA damaging therapeutic agents....

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Topics

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Share to BRCA1 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

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Share to Tumor Suppressor Protein p53

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Source

Identifiers

PMID: 17993233
DOI: 10.1007/978-0-387-74039-3_5

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17993233-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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