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Article

Conversion of omnipotent translation termination factor eRF1 into ciliate-like UGA-only unipotent eRF1.

EMBO reports - 1 Sept 2002

Seit-Nebi Alim, Frolova Ludmila, Kisselev Lev

Abstract excerpt

In eukaryotic ribosomes, termination of translation is triggered by class 1 polypeptide release factor, eRF1. In organisms with a universal code, eRF1 responds to three stop codons, whereas, in ciliates with variant codes, only one or two codon(s) remain(s) as stop signals. By mutagenesis of the Y-C-F minidomain of the N domain, we converted an omnipotent human eRF1 recognizing all three stop codons into a...

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Identifiers

PMID: 12189178
DOI: 10.1093/embo-reports/kvf178
PMCID: PMC1084231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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