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Article

Identification of residues required for stalled-ribosome rescue in the codon-independent release factor YaeJ.

Nucleic acids research - 1 Mar 2014

Kogure Hiroyuki, Handa Yoshihiro, Nagata Masahiro, Kanai Naoto, Güntert Peter, Kubota Kenji, Nameki Nobukazu

Abstract excerpt

The YaeJ protein is a codon-independent release factor with peptidyl-tRNA hydrolysis (PTH) activity, and functions as a stalled-ribosome rescue factor in Escherichia coli. To identify residues required for YaeJ function, we performed mutational analysis for in vitro PTH activity towards rescue of ribosomes stalled on a non-stop mRNA, and for ribosome-binding efficiency. We focused on residues conserved among...

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Identifiers

PMID: 24322300
DOI: 10.1093/nar/gkt1280
PMCID: PMC3950681

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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