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Article

Analysis of protein dimerization and ligand binding of orphan receptor HNF4alpha.

Journal of molecular biology - 29 Sept 2000

Bogan A A, Dallas-Yang Q, Ruse M D, Maeda Y, Jiang G, Nepomuceno L, Scanlan T S, Cohen F E, Sladek F M

Abstract excerpt

Hepatocyte nuclear factor 4alpha (HNF4alpha) (NR2A1), an orphan member of the nuclear receptor superfamily, binds DNA exclusively as a homodimer even though it is very similar in amino acid sequence to retinoid X receptor alpha (RXRalpha), which heterodimerizes readily with other receptors. Here, experimental analysis of residues involved in protein dimerization and studies on a reported ligand for HNF4alpha are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10993727
DOI: 10.1006/jmbi.2000.4099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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