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Structural insights into the HNF4 biology

19 Jun 2023

Abstract excerpt

Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear receptor (NR) family that is expressed in liver, kidney, intestine and pancreas. It is a master regulator of liver-specific gene expression, in particular those genes involved in lipid transport and glucose metabolism and is crucial for the cellular differentiation during development. Dysregulation of HNF4 is linked to...

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PMID: 37404310
DOI: 10.3389/fendo.2023.1197063

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