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Article

Mutation P291fsinsC in the Transcription Factor Hepatocyte Nuclear Factor-1α is Dominant Negative

1 Aug 1998

Abstract excerpt

The type 3 form of maturity-onset diabetes of the young (MODY3) results from mutations in the gene encoding the transcription factor, hepatocyte nuclear factor-1alpha (HNF-1alpha). The mechanism by which mutations in only one allele of the HNF-1alpha gene impair pancreatic beta-cell function is unclear. The functional form of HNF-1alpha is a dimer--either a homodimer or a heterodimer with the structurally related...

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Share to Adenosine and Purinergic Signaling
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PMID: 9703322
DOI: 10.2337/diab.47.8.1231

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Mutation P291fsinsC in the Transcription Factor Hepatocyte Nuclear Factor-1α is Dominant NegativePMID 9703322Read ↗

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Differential effects of HNF-1α mutations associated with familial young-onset diabetes on target gene regulation.Semantic proximity Read ↗

Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha.Semantic proximity Read ↗

Characterization of a naturally occurring mutation (L107I) in the HNF1 alpha (MODY3) gene.Semantic proximity Read ↗

Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences.Semantic proximity Read ↗

Promoter-Specific Repression of Hepatocyte Nuclear Factor (HNF)-1β and HNF-1α Transcriptional Activity by an HNF-1β Missense Mutant Associated with Type 5 Maturity-Onset Diabetes of the Young with Hepatic and Biliary ManifestationsSemantic proximity Read ↗

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