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Article

Distinct amino acid residues may be involved in coactivator and ligand interactions in hepatocyte nuclear factor-4alpha.

The Journal of biological chemistry - 10 Jun 2005

Iordanidou Panagiota, Aggelidou Eleni, Demetriades Constantinos, Hadzopoulou-Cladaras Margarita

Abstract excerpt

Hepatocyte nuclear factor-4 (HNF-4) is a transcription factor of the nuclear hormone receptor superfamily that is constitutively active without the addition of exogenous ligand. Crystallographic analysis of the HNF-4alpha and HNF-4gamma ligand binding domains (LBDs) demonstrated the presence of endogenous ligands that may act as structural cofactors for HNF-4. It was also proposed by crystallographic studies that...

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Source

Identifiers

PMID: 15826954
DOI: 10.1074/jbc.M501221200

Genes

PGC
SRC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Distinct amino acid residues may be involved in coactivator and ligand interactions in hepatocyte nuclear factor-4alpha.PMID 15826954Read ↗

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