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Article

Critical role of residues defining the ligand binding pocket in hepatocyte nuclear factor-4alpha.

The Journal of biological chemistry - 16 Jul 2004

Aggelidou Eleni, Iordanidou Panagiota, Tsantili Panayota, Papadopoulos Georgios, Hadzopoulou-Cladaras Margarita

Abstract excerpt

Hepatocyte nuclear factor-4alpha (HNF-4alpha), a member of the nuclear receptor superfamily, is a crucial regulator of a large number of genes involved in glucose, cholesterol, and fatty acid metabolism. Unlike other members of the superfamily, HNF-4alpha activates transcription in the absence of exogenously added ligand. Recently published crystallographic data show that fatty acids are endogenous ligands for...

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Identifiers

PMID: 15123688
DOI: 10.1074/jbc.M401120200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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