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Article

Identification of critical residues for heterodimerization within the ligand-binding domain of retinoid X receptor.

Molecular endocrinology (Baltimore, Md.) - 1 Mar 1998

Lee S K, Na S Y, Kim H J, Soh J, Choi H S, Lee J W

Abstract excerpt

Nuclear receptors regulate transcription by binding to specific DNA response elements as homodimers or heterodimers with the retinoid X receptors (RXRs). The identity box (I-box), a 40-amino acid region within the ligand-binding domains of RXRs and other nuclear receptors, was recently shown to determine identity in the heterodimeric interactions. Here, we dissected this region in the yeast two-hybrid system by...

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PMID: 9514150
DOI: 10.1210/mend.12.3.0072

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Identification of critical residues for heterodimerization within the ligand-binding domain of retinoid X receptor.PMID 9514150Read ↗

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