Article
Identification of critical residues for heterodimerization within the ligand-binding domain of retinoid X receptor.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 1998
Lee S K, Na S Y, Kim H J, Soh J, Choi H S, Lee J W
Abstract excerpt
Nuclear receptors regulate transcription by binding to specific DNA response elements as homodimers or heterodimers with the retinoid X receptors (RXRs). The identity box (I-box), a 40-amino acid region within the ligand-binding domains of RXRs and other nuclear receptors, was recently shown to d...
Topics
- Amino Acid Sequence
- Animals
- Bacterial Proteins
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Binding Sites
- DNA-Binding Proteins
- Dimerization
- Hepatocyte Nuclear Factor 4
- Humans
- Molecular Sequence Data
- Mutation
- Phosphoproteins
- Rats
- Receptors, Retinoic Acid
- Recombinant Proteins
- Retinoid X Receptors
- Serine Endopeptidases
- Transcription Factors