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Article

No SMAD4 hypermethylation in colorectal cancer.

British journal of cancer - 1 Oct 2000

Roth S, Laiho P, Salovaara R, Launonen V, Aaltonen L A

Abstract excerpt

The chromosome region 18q21 is frequently deleted in colorectal cancers. Three candidate tumour suppressor genes, DCC, SMAD4 and SMAD2, map to this region. The SMAD4(DPC4) gene was recently identified as a candidate pancreatic cancer suppressor gene. It is also a gene for juvenile polyposis tumour predisposition syndrome. Somatic SMAD4 mutations have been detected in some colorectal carcinomas. However, the...

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Share to Adenocarcinoma
Share to Chromosome Deletion
Share to Chromosomes, Human, Pair 18

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Neoplasm Metastasis

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Source

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Identifiers

PMID: 10993648
DOI: 10.1054/bjoc.2000.1387
PMCID: PMC2363563

Genes

SMAD4
DCC
SMAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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No SMAD4 hypermethylation in colorectal cancer.PMID 10993648Read ↗

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