Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inactivation of Smad4 in gastric carcinomas.

Cancer research - 1 Oct 1997

Powell S M, Harper J C, Hamilton S R, Robinson C R, Cummings O W

Abstract excerpt

Allelic loss of chromosome 18q has been noted in intestinal type gastric adenocarcinomas. Smad4 is a gene located at 18q that was recently cloned in humans and found to be significantly altered in pancreatic cancers. We sought to determine whether Smad4 genetic alterations played a significant role in gastric tumorigenesis by studying 35 gastric adenocarcinomas of all histopathological types and pathological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Alleles
Share to Chromosomes, Human, Pair 18

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Loss of Heterozygosity

Share to Microsatellite Repeats

Share to Stomach Neoplasms

Share to Trans-Activators

Source

Identifiers

PMID: 9331080

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inactivation of Smad4 in gastric carcinomas.PMID 9331080Read ↗

Allelic imbalance in chromosome band 18q21 and SMAD4 mutations in ovarian cancers.Semantic proximity Read ↗

Genetics of adenocarcinomas of the small intestine: frequent deletions at chromosome 18q and mutations of the SMAD4 gene.Semantic proximity Read ↗

SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway.Semantic proximity Read ↗

Inactivation of SMAD4 tumor suppressor gene during gastric carcinoma progression.Semantic proximity Read ↗

Expression and mutation analyses of MKK4, a candidate tumour suppressor gene encoded by chromosome 17p, in human gastric adenocarcinoma.Semantic proximity Read ↗

Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal tumorigenesis.Semantic proximity Read ↗

Frequent loss of SMAD4/DPC4 protein in colorectal cancersSemantic proximity Read ↗

Role of Smad4 (DPC4) inactivation in human cancer.Semantic proximity Read ↗

Allelic analysis of serous ovarian carcinoma reveals two putative tumor suppressor loci at 18q22-q23 distal to SMAD4, SMAD2, and DCC.Semantic proximity Read ↗

The 18q21 region in colorectal and pancreatic cancer: independent loss of DCC and DPC4 expression.Semantic proximity Read ↗

Chromosome 18q deletion and Smad4 protein inactivation correlate with liver metastasis: a study matched for T- and N- classificationSemantic proximity Read ↗

SMAD4 haploinsufficiency in small intestinal neuroendocrine tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.