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Article

Inactivation of p16INK4a by CpG hypermethylation is not a frequent event in colorectal cancer.

Journal of surgical oncology - 1 Nov 2003

Norrie Mark W A, Hawkins Nicholas J, Todd Alison V, Meagher Alan P, O'Connor Terence W, Ward Robyn L

Abstract excerpt

BACKGROUND AND OBJECTIVES: Gene promoter hypermethylation is common in colorectal cancer and is associated with transcriptional silencing. However, the clinicopathological significance of p16(INK4a) gene silencing with hypermethylation is unknown. Therefore, the aim of this study was to analyze loss of p16 expression and its relationship to hypermethylation in sporadic colorectal cancer. METHODS: Tissue from 426...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14598358
DOI: 10.1002/jso.10310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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