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Article

Role of Smad4 (DPC4) inactivation in human cancer.

Biochemical and biophysical research communications - 11 Jul 2003

Miyaki Michiko, Kuroki Toshio

Abstract excerpt

The tumor suppressor gene Smad4 (DPC4) at chromosome 18q21.1 belongs to the Smad family, which mediates the TGFbeta signaling pathway suppressing epithelial cell growth. This review summarizes the mutational events of the Smad4 gene in human cancer. The Smad4 gene is genetically responsible for familial juvenile polyposis, an autosomal dominant disease characterized by predisposition to gastrointestinal polyps...

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PMID: 12821112
DOI: 10.1016/s0006-291x(03)01066-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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