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Article

Infrequent mutation of the tumour-suppressor gene Smad4 in early-stage colorectal cancer.

British journal of cancer - 10 Feb 2003

Mamot C, Mild G, Reuter J, Laffer U, Metzger U, Terracciano L, Boulay J-L, Herrmann R, Rochlitz C

Abstract excerpt

Smad4 is a candidate tumour-suppressor gene identified recently on chromosome 18q21.1. Both alleles are inactivated in nearly one-half of pancreatic carcinomas, but its role in the tumorigenesis of other tumours is still unknown. The aim of this study was to investigate the potential involvement of the Smad4 locus in early-stage colorectal cancers (stages I-III) in tumour samples from a randomised multicentre...

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Identifiers

PMID: 12569386
DOI: 10.1038/sj.bjc.6600733
PMCID: PMC2747552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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