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Article

The hTERT Gene Is Embedded in a Nuclease-resistant Chromatin Domain

1 Nov 2004

Abstract excerpt

Normal human cells rarely undergo spontaneous immortalization. Given that ectopic expression of the human telomerase catalytic subunit hTERT leads to cellular immortalization, the endogenous hTERT gene is likely constitutively repressed. Hence, we have examined the chromatin structure of the native hTERT locus and the neighboring loci, CRR9 and Xtrp2, in normal human fibroblasts and a set of immortal lines. Using...

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Share to Chromosomal and Genetic Variations
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Share to Telomeres, Telomerase, and Senescence

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PMID: 15516693
DOI: 10.1074/jbc.m411352200

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