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Article

Telomerase Promoter Reprogramming and Interaction with General Transcription Factors in the Human Mesenchymal Stem Cell

23 Dec 2005

Abstract excerpt

The human adult mesenchymal stem cell (hMSC) does not express telomerase and has been shown to be the target for neoplastic transformation after transduction with hTERT. These findings lend support to the stem cell hypothesis of cancer development but by supplying hTERT, the molecular events required to upregulate hTERT expression in cancer development are missed. Therefore, the hMSC is ideal for the...

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Share to Genomics and Chromatin Dynamics
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Share to Telomeres, Telomerase, and Senescence

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PMID: 17465827
DOI: 10.2217/17460751.1.1.125

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