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Chromatin remodeling: recruitment of histone demethylase RBP2 by Madl for transcriptional repression of a Myc target gene, telomerase reverse transcriptase

17 Sept 2009

Abstract excerpt

The Myc/Max/Mad network transcription factors are known to govern target gene expression through recruiting histone acetyltransferases or deacetylases. In the present study, we show that Madl recruits the histone demethylase RBP2 to the Myc target telomerase reverse transcriptase ( hTERT ) gene promoter to repress transcription. With differentiation of leukemic HL60 cells, Madl and RBP2 were both up‐regulated,...

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Share to Epigenetics and DNA Methylation
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PMID: 19762557
DOI: 10.1096/fj.09-140087

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