Article
Histone deacetylase 3 represses HTLV-1 tax transcription.
Oncology reports - 1 Sept 2006
Villanueva Raul, Iglesias Antonio H, Camelo Sandra, Sanin Luis C, Gray Steven G, Dangond Fernando
Abstract excerpt
We examined the epigenetic mechanisms involved in human T-cell lymphotropic virus type 1 (HTLV-1) Tax expression. Blockade of histone deacetylation with trichostatin A (TSA) resulted in Tax upregulation. Using a chromatin immunoprecipitation (ChIP) assay, we verified local histone hyperacetylatio...
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