Role of the Cro repressor carboxy-terminal domain and flexible dimer linkage in operator and nonspecific DNA binding.

doi:10.1021/bi00491a019

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Article

Role of the Cro repressor carboxy-terminal domain and flexible dimer linkage in operator and nonspecific DNA binding.

Biochemistry - 2 Oct 1990

Hubbard A J, Bracco L P, Eisenbeis S J, Gayle R B, Beaton G, Caruthers M H

Abstract excerpt

A series of mutations comprising single and multiple substitutions, deletions, and extensions within the carboxy-terminal domain of the bacteriophage lambda Cro repressor have been constructed. These mutations generally affect the affinity of repressor for specific and nonspecific DNA. Additional...

Topics

Amino Acid Sequence
Base Sequence
Cloning, Molecular
DNA
Molecular Sequence Data
Mutation
Operator Regions, Genetic
Repressor Proteins

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