Article
Retroevolution of lambda Cro toward a stable monomer.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003
LeFevre Kelly R, Cordes Matthew H J
Abstract excerpt
The Cro protein from bacteriophage lambda has a dimeric alpha+beta fold that evolved from an ancestral all-alpha monomer. The sequence mutations responsible for this dramatic structural evolution are unknown. Here we use analysis of sequence alignments to show that Ala-33, a small side chain in the hydrophobic "ball-and-socket" dimer interface of lambda Cro, was a much larger tryptophan side chain at a previous...
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