Article
A common polymorphism associated with antibiotic-induced cardiac arrhythmia.
Proceedings of the National Academy of Sciences of the United States of America - 12 Sept 2000
Sesti F, Abbott G W, Wei J, Murray K T, Saksena S, Schwartz P J, Priori S G, Roden D M, George A L, Goldstein S A
Abstract excerpt
Drug-induced long QT syndrome (LQTS) is a prevalent disorder of uncertain etiology that predisposes to sudden death. KCNE2 encodes MinK-related peptide 1 (MiRP1), a subunit of the cardiac potassium channel I(Kr) that has been associated previously with inherited LQTS. Here, we examine KCNE2 in 98 patients with drug-induced LQTS, identifying three individuals with sporadic mutations and a patient with...
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