A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes.

doi:10.1161/CIRCGENETICS.111.960930

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Article

A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes.

Circulation. Cardiovascular genetics - 1 Feb 2012

Kääb Stefan, Crawford Dana C, Sinner Moritz F, Behr Elijah R, Kannankeril Prince J, Wilde Arthur A M, Bezzina Connie R, Schulze-Bahr Eric, Guicheney Pascale, Bishopric Nanette H, Myerburg Robert J, Schott Jean-Jacques, Pfeufer Arne, Beckmann Britt-Maria, Martens Eimo, Zhang Taifang, Stallmeyer Birgit, Zumhagen Sven, Denjoy Isabelle, Bardai Abdennasser, Van Gelder Isabelle C, Jamshidi Yalda, Dalageorgou Chrysoula, Marshall Vanessa, Jeffery Steve, Shakir Saad, Camm A John, Steinbeck Gerhard, Perz Siegfried, Lichtner Peter, Meitinger Thomas, Peters Annette, Wichmann H-Erich, Ingram Christiana, Bradford Yuki, Carter Shannon, Norris Kris, Ritchie Marylyn D, George Alfred L, Roden Dan M

Abstract excerpt

BACKGROUND: Drug-induced long-QT syndrome (diLQTS) is an adverse drug effect that has an important impact on drug use, development, and regulation. We tested the hypothesis that common variants in key genes controlling cardiac electric properties modify the risk of diLQTS. METHODS AND RESULTS: In a case-control setting, we included 176 patients of European descent from North America and Europe with diLQTS,...

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Identifiers

PMID: 22100668
DOI: 10.1161/CIRCGENETICS.111.960930
PMCID: PMC3288202

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