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Article

Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients.

Journal of molecular medicine (Berlin, Germany) - 1 Mar 2004

Paulussen Aimée D C, Gilissen Ronaldus A H J, Armstrong Martin, Doevendans Pieter A, Verhasselt Peter, Smeets Hubert J M, Schulze-Bahr Eric, Haverkamp Wilhelm, Breithardt Günter, Cohen Nadine, Aerssens Jeroen

Abstract excerpt

Administration of specific drugs may occasionally induce acquired long QT syndrome (aLQTS), a disorder that predisposes to ventricular arrhythmias, typically of the torsade de pointes (TdP) type, and sudden cardiac death. "Forme fruste" mutations in congenital LQTS (cLQTS) genes have been reporte...

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Source

Identifiers

PMID: 14760488
DOI: 10.1007/s00109-003-0522-z

Genes

KCNH2
KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14760488-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients.PMID 14760488Read ↗

Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes.Semantic proximity Read ↗

Novel rare variants in congenital cardiac arrhythmia genes are frequent in drug-induced torsades de pointes.Semantic proximity Read ↗

Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome.Semantic proximity Read ↗

Genetics of congenital and drug-induced long QT syndromes: current evidence and future research perspectives.Semantic proximity Read ↗

The genetics underlying acquired long QT syndrome: impact for genetic screening.Semantic proximity Read ↗

Association of torsades de pointes with novel and known single nucleotide polymorphisms in long QT syndrome genes.Semantic proximity Read ↗

A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes.Semantic proximity Read ↗

Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing.Semantic proximity Read ↗

Drug-induced torsades de pointes: the evolving role of pharmacogenetics.Semantic proximity Read ↗

Spectrum and prevalence of mutations from the first 2,500 consecutive unrelated patients referred for the FAMILION long QT syndrome genetic test.Semantic proximity Read ↗

Spectrum of pathogenic mutations and associated polymorphisms in a cohort of 44 unrelated patients with long QT syndrome.Semantic proximity Read ↗

D85N, a KCNE1 polymorphism, is a disease-causing gene variant in long QT syndrome.Semantic proximity Read ↗

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