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Article

Regulation of the Kv2.1 potassium channel by MinK and MiRP1.

The Journal of membrane biology - 1 Mar 2009

McCrossan Zoe A, Roepke Torsten K, Lewis Anthony, Panaghie Gianina, Abbott Geoffrey W

Abstract excerpt

Kv2.1 is a voltage-gated potassium (Kv) channel alpha-subunit expressed in mammalian heart and brain. MinK-related peptides (MiRPs), encoded by KCNE genes, are single-transmembrane domain ancillary subunits that form complexes with Kv channel alpha-subunits to modify their function. Mutations in human MinK (KCNE1) and MiRP1 (KCNE2) are associated with inherited and acquired forms of long QT syndrome (LQTS). Here,...

Topics

Animals
Blotting, Western
CHO Cells
Cricetinae
Cricetulus
Electrophysiology
Fluorescent Antibody Technique
Humans
Immunoprecipitation
Mutation
Myocardium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Potassium Channels, Voltage-Gated

Rats

Reverse Transcriptase Polymerase Chain Reaction

Shab Potassium Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 19219384
DOI: 10.1007/s00232-009-9154-8
PMCID: PMC2849987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Regulation of the Kv2.1 potassium channel by MinK and MiRP1.PMID 19219384Read ↗

Does hERG coassemble with a beta subunit? Evidence for roles of MinK and MiRP1.Semantic proximity Read ↗

Disease‐associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanismSemantic proximity Read ↗

A superfamily of small potassium channel subunits: form and function of the MinK-related peptides (MiRPs).Semantic proximity Read ↗

Dominant-negative Effect of MinK-A8V Impairs I Ks and Disturbs Channel Structure: Importance of Clinical Surveillance in Mild LQTS Patients and Asymptomatic CarriersSemantic proximity Read ↗

Mutant MiRP1 subunits modulate HERG K+ channel gating: a mechanism for pro-arrhythmia in long QT syndrome type 6.Semantic proximity Read ↗

MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac ArrhythmiaSemantic proximity Read ↗

An LQT mutant minK alters KvLQT1 trafficking.Semantic proximity Read ↗

Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics.Semantic proximity Read ↗

Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome.Semantic proximity Read ↗

N- and C-terminal KCNE1 mutations cause distinct phenotypes of long QT syndrome.Semantic proximity Read ↗

KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium currentSemantic proximity Read ↗

Subunit composition of minK potassium channels.Semantic proximity Read ↗

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