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Article

Regulation of the Kv2.1 potassium channel by MinK and MiRP1.

The Journal of membrane biology - 1 Mar 2009

McCrossan Zoe A, Roepke Torsten K, Lewis Anthony, Panaghie Gianina, Abbott Geoffrey W

Abstract excerpt

Kv2.1 is a voltage-gated potassium (Kv) channel alpha-subunit expressed in mammalian heart and brain. MinK-related peptides (MiRPs), encoded by KCNE genes, are single-transmembrane domain ancillary subunits that form complexes with Kv channel alpha-subunits to modify their function. Mutations in human MinK (KCNE1) and MiRP1 (KCNE2) are associated with inherited and acquired forms of long QT syndrome (LQTS). Here,...

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Identifiers

PMID: 19219384
DOI: 10.1007/s00232-009-9154-8
PMCID: PMC2849987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Regulation of the Kv2.1 potassium channel by MinK and MiRP1.PMID 19219384Read ↗

Does hERG coassemble with a beta subunit? Evidence for roles of MinK and MiRP1.Semantic proximity Read ↗

Disease‐associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanismSemantic proximity Read ↗

A superfamily of small potassium channel subunits: form and function of the MinK-related peptides (MiRPs).Semantic proximity Read ↗

Dominant-negative Effect of MinK-A8V Impairs I Ks and Disturbs Channel Structure: Importance of Clinical Surveillance in Mild LQTS Patients and Asymptomatic CarriersSemantic proximity Read ↗

Mutant MiRP1 subunits modulate HERG K+ channel gating: a mechanism for pro-arrhythmia in long QT syndrome type 6.Semantic proximity Read ↗

MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac ArrhythmiaSemantic proximity Read ↗

An LQT mutant minK alters KvLQT1 trafficking.Semantic proximity Read ↗

Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics.Semantic proximity Read ↗

Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome.Semantic proximity Read ↗

N- and C-terminal KCNE1 mutations cause distinct phenotypes of long QT syndrome.Semantic proximity Read ↗

KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium currentSemantic proximity Read ↗

Subunit composition of minK potassium channels.Semantic proximity Read ↗

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