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Article

Novel rare variants in congenital cardiac arrhythmia genes are frequent in drug-induced torsades de pointes.

The pharmacogenomics journal - 1 Aug 2013

Ramirez A H, Shaffer C M, Delaney J T, Sexton D P, Levy S E, Rieder M J, Nickerson D A, George A L, Roden D M

Abstract excerpt

Marked prolongation of the QT interval and polymorphic ventricular tachycardia following medication (drug-induced long QT syndrome, diLQTS) is a severe adverse drug reaction (ADR) that phenocopies congenital long QT syndrome (cLQTS) and is one of the leading causes for drug withdrawal and relabel...

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Share to Arrhythmias, Cardiac
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22584458
DOI: 10.1038/tpj.2012.14
PMCID: PMC3422407

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-22584458-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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