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Article

Novel rare variants in congenital cardiac arrhythmia genes are frequent in drug-induced torsades de pointes.

The pharmacogenomics journal - 1 Aug 2013

Ramirez A H, Shaffer C M, Delaney J T, Sexton D P, Levy S E, Rieder M J, Nickerson D A, George A L, Roden D M

Abstract excerpt

Marked prolongation of the QT interval and polymorphic ventricular tachycardia following medication (drug-induced long QT syndrome, diLQTS) is a severe adverse drug reaction (ADR) that phenocopies congenital long QT syndrome (cLQTS) and is one of the leading causes for drug withdrawal and relabeling. We evaluated the frequency of rare non-synonymous variants in genes contributing to the maintenance of heart...

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Source

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Identifiers

PMID: 22584458
DOI: 10.1038/tpj.2012.14
PMCID: PMC3422407

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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